Evaluation of secondary metabolites profile and antioxidant potential of Terminalia chebula and Glycyrrhiza glabra

Abstract

This study explores the antioxidant potential and secondary metabolite profiles of Terminalia chebula and Glycyrrhiza glabra, medicinal plants native to Swat, Pakistan. Terminalia chebula, or black myrobalan, is known for its antioxidant and anti-inflammatory properties, while Glycyrrhiza glabra, commonly known as licorice, has a rich history of traditional medicinal use for over 4000 years. The study focuses on evaluating the total phenolic and flavonoid contents, as well as the antioxidant activity of both plants. The study explores the importance of secondary metabolites, including alkaloids, glycosides, flavonoids, phenolics, saponins, tannins, terpenes, anthraquinones, essential oils, and steroids, in both Terminalia chebula and Glycyrrhiza glabra. The antioxidant activity of these plants is crucial in combating oxidative stress and preventing various health conditions associated with reactive oxygen species (ROS). The methodology involves the collection of seeds from local markets, grinding them into powder, and extracting them with 70% ethanol. The samples are then subjected to various analyses, including total phenolic and flavonoid content determination and antioxidant activity evaluation using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay. Results indicate that both Terminalia chebula and Glycyrrhiza glabra exhibit significant levels of total phenolic and flavonoid contents, with remarkable antioxidant activity. Glycyrrhiza glabra demonstrates higher total phenolic and flavonoid contents compared to Terminalia chebula. The study concludes that these medicinal plants are rich sources of bioactive compounds with potential therapeutic applications, highlighting the importance of exploring and harnessing the pharmacological benefits of traditional medicinal plants for human health. © 2020 The Author(s)